Paddington Station opened in 1838.
Paddington is the terminus for the Great Western Main line, which is currently operated by Great Western Railway.
Channel 5 have recently done a series of episodes here, called Paddington Station 24/7. I would highly recommend it.
A crossrail station is well underway at Paddington. ~~Crossrail services are due to start in December of 2018.~~ Crossrail dates have currently been postponed.